![]() ![]() ![]() The pathogenesis and pathophysiology of IBS are complex and remain incompletely understood. It seriously affects quality of life and consumes vast medical resources. About 10–20% of adults in western countries and 5–10% of Asian adults are affected by IBS. Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder (FGID) characterised by recurrent abdominal pain or discomfort associated with alterations in stool frequency and/or consistency, for which there is no apparent physical or biochemical cause to explain the symptoms. The serum IL-10 level was significantly lower in SIBO-positive than SIBO-negative patients with IBS. Psychological disorders were not associated with SIBO in patients with IBS. Patients with IBS had higher anxiety, depression, and LES scores, but anxiety, depression, and LES scores were similar between the SIBO-positive and SIBO-negative groups. ![]() The prevalence of SIBO in patients with IBS was higher than that in healthy controls (39% versus 8%, resp. The 89 enrolled patients with IBS and 13 healthy controls had no differences in baseline characteristics. Serum tumour necrosis factor- α, interleukin- (IL-) 6, IL-8, and IL-10 levels were measured. All participants also completed a face-to-face questionnaire survey, including the Hospital Anxiety and Depression Scale, Life Event Stress (LES), and general information. In total, 94 patients with IBS and 13 healthy volunteers underwent a 10 g lactulose hydrogen breath test (HBT) with concurrent scintigraphy. Psychosocial factors and low-grade colonic mucosal immune activation have been suggested to play important roles in the pathophysiology of IBS. Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathogenesis of irritable bowel syndrome (IBS). ![]()
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